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. 2015 Sep 2;290(43):26235–26248. doi: 10.1074/jbc.M115.672097

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© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 8. — N55 enhances GLP-1(7–36)-amide- dependent GLP-1R endocytosis. Receptor endocytosis assays were performed in U2OS cells co-expression β-arrestin2-GFP and GLP-1R-V2R in the presence of indicated concentrations of GLP-1(7–36)-amide and N55. A, response of GLP-1R endocytosis to the titration of GLP-1 in the absence (black circles) or presence (green triangles) of 7.7 μm N55. B, N55 dose-dependently and saturably enhances GLP-1R endocytosis elicited by 1 nm GLP-1(7–36)-amide. All data are mean ± S.E. of triplicates from three independent experiments.