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N55 enhances GLP-1-elicited insulin release from RINm5F cells. Effects of various compounds on insulin release from RINm5F cells are shown. Stimulation of RINm5F cells and assays for insulin release were described under “Experimental Procedures.” Data are means ± S.E. (error bars) of duplicate assays from three independent experiments. Student's t test (★, p < 0.005; ★★★, p < 0.001) for insulin release by vehicle versus the presence of indicated compounds.
