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. 2015 Nov 16;10(11):e0142836. doi: 10.1371/journal.pone.0142836

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© 2015 Novak et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 2 — (A) Heart muscle (TinC Gal4) RNAi knockdown of dFmr1 (TinC Gal4> dFmr1 ^RNAi-1, N = 10 and dFmr1 ^RNAi-2, N = 10) results in a significant decrease in heart rate compared to control (TinC Gal4> w ¹¹¹⁸, N = 17). (B) Neuronal-specific (Elav Gal4) and (C) panglial (Repo Gal4) RNAi knockdown of dFmr1 (dFmr1 ^RNAi-1, N = 11 and dFmr1 ^RNAi-2, N = 11) do not result in a significant decrease in heart rate compared to control (w ¹¹¹⁸, N = 11). Student’s T-test was used to calculate statistical significance: p values, n.s. = no significance, * <0.05, ** <0.01, *** <0.001. (D) Dorsal vessel of the RNAi knockdown of dFmr1 (TinC Gal4> dFmr1 ^RNAi-2, dFmr1 ^RNAi-2) stained with anti-dFmr1 (shown in green) results in a visible decrease in dFmr1 expression compared to control (TinC Gal4> w ¹¹¹⁸, Control), as seen in the pericardial cells (P) and the cardiomyocytes. Scale bar = 20 μm. (E) No major changes in sarcomere structure as seen by staining for filamentous actin could be detected. Scale bar = 2 μm.