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Model. Ac2PIM-responsive, TLR2-SRC-FAK-PYK2-CREB-CBP/P300-dependent miRNAs, miR-150 and miR-143, target RIP2 and TAK1, respectively to suppress NOD2-induced PI3K-PKCδ-MAPK-β-catenin-mediated expression of immunomodulators like COX-2, SOCS-3, and MMP-9.
