Skip to main content
. 2015 Sep 9;290(44):26597–26609. doi: 10.1074/jbc.M115.673301

TABLE 1.

Deamination t½ and yields for CPD formation in the FOS promoter in vitro and in vivo

CPD 1 CPD 2 CPD 3 CPD 4
In vitro
    t½ (h) 4.8 ± 2.2 6.7 ± 3.2 3.2 ± 0.9 4.0 ± 1.0
    Relative rates 1 0.72 ± 0.47 1.5 ± 0.8 1.2 ± 0.6
    Relative yield (curve fit) 1 0.31 ± 0.06 0.38 ± 0.07 0.36 ± 0.06
    Relative yield (gel, 48 h) 1 0.39 0.47 0.34

In vivo 1
    t½ 7.8 ± 4.6 4.7 ± 1.3 3.9 ± 0.9
    Relative rates 1 1.7 ± 1.1 2.0 ± 1.3
    Relative yield (curve fit) 1 0.62 ± 0.15 0.63 ± 0.15
    Relative yield (gel 70 h) 1 0.15 0.48 0.70

In vivo 2
    t½ 15.8 ± 6.8 5.3 ± 1.5 7.6 ± 4.2
    Relative rates 1 3.0 ± 1.5 2.1 ± 1.5
    Relative yield (curve fit) 1 0.40 ± 0.11 0.32 ± 0.10
    Relative yield (gel 70 h) 1 0.14 0.47 0.67

Average of 1 and 2
    t½ 11.8 ± 8.2 5.0 ± 2 5.7 ± 4.3
    Relative rates 1 2.1 ± 1,0 2.0 ± 1.0
    Relative yield (curve fit) 1 0.48 ± 0.09 0.43 ± 0.09
    Relative yield (gel 70 h) 1 0.14 0.47 0.67

Rate change
    In vivo/in vitro 0.46 ± 0.2 0.63 ± 0.30 0.78 ± 0.23
    Relative to CPD1 1 1.4 ± 0.9 1.70 ± 0.9

Predicted
    Position 2: −1 1 4.3 ± 0.7 4.3 ± 0.7
    Position 3: 0 1 2.5 ± 0.3 2.5 ± 0.3
    Position 4: 1 1 0.5 ± 0.1 0.5 ± 0.1
HHS Vulnerability Disclosure