Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
IC50 values for inhibition of ERK2 by the indicated D-site peptides
The concentration of D-site peptide required to inhibit ERK2 phosphorylation of Elk-1 by 50% (the IC50 value) is shown for the indicated peptides.
| D-site peptide | IC50 for inhibition of ERK2 phosphorylation of Elk-1 | Increase in IC50 (relative to WT) |
|---|---|---|
| μm | -fold | |
| MEK2 WT (LXIXP) | 9 | |
| MEK2 I14L | 11 | 1.2 |
| MEK2 P16L | 13 | 1.4 |
| MEK2 LXLXL | 14 | 1.5 |
