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. 2015 Sep 10;290(44):26699–26714. doi: 10.1074/jbc.M115.678433

FIGURE 1.

FIGURE 1.

Mlip-deficient mice have normal cardiac structure and function. A, generation of Mlip KO mouse model by deletion of the first exon of the Mlip gene and its proximal promoter. B, genotyping and photographs of adult Mlip+/+ and Mlip−/− mice. C, Western blot of MLIP, A- and B-type lamins in Mlip+/+ and Mlip−/− hearts. D, Mlip+/+ cardiac sections stained with MLIP (red), vinculin, or α-actinin (green) antibodies. Nuclei were counterstained with DAPI (blue). Scale bars, 20 μm. E, HW:BW ratio of Mlip+/+ and Mlip−/− male mice (n = 3–8 per genotype and age, means ± S.D.). F, lung weight (LW):BW ratio of Mlip+/+ and Mlip−/− male mice (n = 3–8 per genotype and age, means ± S.D.). G, echocardiographic measurements values of 12-week-old Mlip+/+ and Mlip−/− male mice in diastole (d) and systole (s). IVS, interventricular septum; LVID, left ventricular internal diameter; FS, fractional shortening; EF, ejection fraction (n = 7 per genotype, means ± S.D.). Student's t test was used.