FIGURE 7.
Mlip is genetically associated with early cardiac hypertrophy. A, timeline of isoproterenol infusion (20 mg·kg−1·day−1) used in the genome-wide association study. B and C, Manhattan plot showing the association between genotype and IVSd at after 1 (B) and 2 (C) weeks of isoproterenol infusion. The red line represents the statistical threshold. D, regional association plot with interventricular septum thickness in diastole in response to isoproterenol (week 1), with linkage disequilibrium denoted by r2. E, characteristics of the two SNPs in Mlip gene associated with differential hypertrophy of the IVSd. F, Mlip mRNA level after 3 weeks of isoproterenol treatment in all mouse strains (means ± S.D.). ***, p < 0.001, paired t test.