TABLE 2.
Metabolic parameters of 12-week-old Mlip+/+ and Mlip−/− male mice
BW, body weight; WAT, abdominal white adipose tissue; BAT, brown adipose tissue; GIP, gastric inhibitory polypeptide; PAI-1, plasminogen activator inhibitor 1; GLP-1, glucagon-like peptide 1.
| Mlip+/+ | Mlip−/− | p value | n | |
|---|---|---|---|---|
| BW (g) | 24.8 ± 2.3 | 25.9 ± 2.6 | 0.181 | 17/19 |
| WAT weight (mg) | 348.7 ± 149.2 | 458.0 ± 266.7 | 0.387 | 6/8 |
| WAT weight to BW (mg/g) | 14.8 ± 6.9 | 17.1 ± 8.1 | 0.573 | 6/8 |
| BAT weight (mg) | 94.0 ± 18.0 | 125.6 ± 63.0 | 0.259 | 6/8 |
| BAT weight to BW (mg/g) | 3.91 ± 0.75 | 4.70 ± 1.76 | 0.326 | 6/8 |
| Liver weight (mg) | 931.7 ± 121.6 | 980.9 ± 103.7 | 0.430 | 6/8 |
| Liver weight to BW (mg/g) | 38.6 ± 3.7 | 37.6 ± 4.0 | 0.713 | 6/8 |
| Fasted blood glucose (mmol/liter) | 6.76 ± 0.84 | 6.81 ± 1.01 | 0.869 | 17/18 |
| Hormones levels (pg/ml) | ||||
| Resistin | 106,632 ± 25,988 | 116,911 ± 34,038 | 0.466 | 11/9 |
| GIP | 553 ± 159 | 575 ± 145 | 0.743 | 11/9 |
| PAI-1 | 4225 ± 1468 | 3744 ± 1381 | 0.461 | 11/9 |
| GLP-1 | 58 ± 25 | 56 ± 16 | 0.756 | 11/9 |
| Glucagon | 298 ± 94 | 283 ± 35 | 0.637 | 11/9 |
| Ghrelin | 31,634 ± 7469 | 24,031 ± 11,723 | 0.110 | 11/9 |
| Leptin | 2939 ± 1924 | 3794 ± 2505 | 0.412 | 11/9 |
| Insulin | 2212 ± 639 | 2585 ± 729 | 0.244 | 11/9 |
| Respiratory exchange rate | ||||
| Light | 0.889 ± 0.030 | 0.870 ± 0.046 | 0.466 | 5/6 |
| Dark | 0.921 ± 0.025 | 0.909 ± 0.045 | 0.602 | 5/6 |