Table 2. Characteristics of the responses evoked on the same SNr cell by electrical stimulation of the motor cortex in the different conditions.
| A—In control condition and after systemic injection of haloperidol | ||||||||
| Early excitation | Inhibition | Late excitation | ||||||
| N = 7 | L (ms) | D (ms) | Nb Sp | L (ms) | D (ms) | L (ms) | D (ms) | Nb Sp |
| Control | 7.4±1.6 | 6.6±1.0 | 18.7±6.7 | 17.1±2.1 | 16.6±2.7 | 29.2±6.0 | 12.0±3.4 | 19.3±4.7 |
| Haloperidol Alone | 6.6±1.0 | 7.6±0.8 | 18.0±7.1 | 18.0±1.9 | 21.4±5.3 | 32.5±1.6 | 12.0±2.0 | 40.3±7.1* 1 |
| B—In control condition and after systemic injection of haloperidol + bee venom | ||||||||
| Early excitation | Inhibition | Late excitation | ||||||
| N = 7 | L (ms) | D (ms) | Nb Sp | L (ms) | D (ms) | L (ms) | D (ms) | Nb Sp |
| Control | 6.3±0.7 | 6.3±0.7 | 34.0±8.9 | 15.6±0.7 | 19.1± 0.7 | 36.1±0.8 | 7.9±1.3 | 59.5±23.1 |
| haloperidol + BV | 5.8±0.6 | 7.6±1.1 | 44.7±14.5 | 14.4±0.9 | 20.0±1.1 | 35.7±1.5 | 8.4±0.8 | 58.3±27.3 |
| C—In control condition, after systemic injection of neuroleptics and after systemic injection of bee venom | ||||||||
| Early excitation | Inhibition | Late excitation | ||||||
| N = 7 | L (ms) | D (ms) | Nb Sp | L (ms) | D (ms) | L (ms) | D (ms) | Nb Sp |
| Control | 9.0±0.4 | 6.6± 0.9 | 16.8±2.9 | 17.9±0.9 | 13.3±1.8 | 31.1±2.3 | 15.1±2.4 | 27.6±5.3 |
| SCH 23390 + Raclopride | 9.6±0.8 | 7.1±0.7 | 17.3±5.0 | 21.0±1.5 | 4.0±1.0* 2 | 25.6±1.8* 3 | 19.9±1.3* 4 | 47.6±12.7 |
| SCH 23390 + Raclopride + BV | 10.7±1.4 | 5.6±0.6 | 20.1±3.7 | 18.7±1.0 | 10.7±1.3 | 29.4±0.9 | 13.8±1.9 | 50.7±13.1 |
| D—In 6-OHDA lesioned animal and after systemic injection of bee venom | ||||||||
| Early excitation | Inhibition | Late excitation | ||||||
| N = 8 | L (ms) | D (ms) | Nb Sp | L (ms) | D (ms) | L (ms) | D (ms) | Nb Sp |
| 6-OHDA | 7.0±0.9 | 8.2±1.2 | 19.5±5.6 | 16.1±1.1 | 18.7±1.3 | 34.1±3.2 | 18.2±2.5 | 38.7±11.9 |
| 6-OHDA + BV | 7.6±1.1 | 7.7±1.5 | 19.0±5.9 | 16.2±1.1 | 25.1±2.4* 5 | 34.3±3.1 | 19.1±2.9 | 39.2±12.8 |
The latency (L) and duration (D) of the different components of the cortically-evoked response were measured on the basis of post-stimulus time histograms generated from 50 cortical stimulations. Nb Sp: number of spikes.
A: *1 p = 0.016, Paired t-test; B: N.S., Paired t-test; C: *2: p < 0.001, One way Repeated Measures Analysis of Variance; *3: p = 0.027, One way Repeated Measures Analysis of Variance; *4: p = 0.021, One way Repeated Measures Analysis of Variance (Holm-Sidak Method for all RM ANOVA); D: *5 p = 0.012, Paired t-test. Nb Sp: number of spikes.