Table 2. Characteristics of the responses evoked on the same SNr cell by electrical stimulation of the motor cortex in the different conditions.
A—In control condition and after systemic injection of haloperidol | ||||||||
Early excitation | Inhibition | Late excitation | ||||||
N = 7 | L (ms) | D (ms) | Nb Sp | L (ms) | D (ms) | L (ms) | D (ms) | Nb Sp |
Control | 7.4±1.6 | 6.6±1.0 | 18.7±6.7 | 17.1±2.1 | 16.6±2.7 | 29.2±6.0 | 12.0±3.4 | 19.3±4.7 |
Haloperidol Alone | 6.6±1.0 | 7.6±0.8 | 18.0±7.1 | 18.0±1.9 | 21.4±5.3 | 32.5±1.6 | 12.0±2.0 | 40.3±7.1* 1 |
B—In control condition and after systemic injection of haloperidol + bee venom | ||||||||
Early excitation | Inhibition | Late excitation | ||||||
N = 7 | L (ms) | D (ms) | Nb Sp | L (ms) | D (ms) | L (ms) | D (ms) | Nb Sp |
Control | 6.3±0.7 | 6.3±0.7 | 34.0±8.9 | 15.6±0.7 | 19.1± 0.7 | 36.1±0.8 | 7.9±1.3 | 59.5±23.1 |
haloperidol + BV | 5.8±0.6 | 7.6±1.1 | 44.7±14.5 | 14.4±0.9 | 20.0±1.1 | 35.7±1.5 | 8.4±0.8 | 58.3±27.3 |
C—In control condition, after systemic injection of neuroleptics and after systemic injection of bee venom | ||||||||
Early excitation | Inhibition | Late excitation | ||||||
N = 7 | L (ms) | D (ms) | Nb Sp | L (ms) | D (ms) | L (ms) | D (ms) | Nb Sp |
Control | 9.0±0.4 | 6.6± 0.9 | 16.8±2.9 | 17.9±0.9 | 13.3±1.8 | 31.1±2.3 | 15.1±2.4 | 27.6±5.3 |
SCH 23390 + Raclopride | 9.6±0.8 | 7.1±0.7 | 17.3±5.0 | 21.0±1.5 | 4.0±1.0* 2 | 25.6±1.8* 3 | 19.9±1.3* 4 | 47.6±12.7 |
SCH 23390 + Raclopride + BV | 10.7±1.4 | 5.6±0.6 | 20.1±3.7 | 18.7±1.0 | 10.7±1.3 | 29.4±0.9 | 13.8±1.9 | 50.7±13.1 |
D—In 6-OHDA lesioned animal and after systemic injection of bee venom | ||||||||
Early excitation | Inhibition | Late excitation | ||||||
N = 8 | L (ms) | D (ms) | Nb Sp | L (ms) | D (ms) | L (ms) | D (ms) | Nb Sp |
6-OHDA | 7.0±0.9 | 8.2±1.2 | 19.5±5.6 | 16.1±1.1 | 18.7±1.3 | 34.1±3.2 | 18.2±2.5 | 38.7±11.9 |
6-OHDA + BV | 7.6±1.1 | 7.7±1.5 | 19.0±5.9 | 16.2±1.1 | 25.1±2.4* 5 | 34.3±3.1 | 19.1±2.9 | 39.2±12.8 |
The latency (L) and duration (D) of the different components of the cortically-evoked response were measured on the basis of post-stimulus time histograms generated from 50 cortical stimulations. Nb Sp: number of spikes.
A: *1 p = 0.016, Paired t-test; B: N.S., Paired t-test; C: *2: p < 0.001, One way Repeated Measures Analysis of Variance; *3: p = 0.027, One way Repeated Measures Analysis of Variance; *4: p = 0.021, One way Repeated Measures Analysis of Variance (Holm-Sidak Method for all RM ANOVA); D: *5 p = 0.012, Paired t-test. Nb Sp: number of spikes.