TABLE 2.

Summary of the TRS-selected candidates validated by dose-response Luciferase assays

For each of the factors, the data were normalized to the lowest dose employed in the study. Values above or below the reference value are color-coded: in graded greens for activation and in graded reds for inhibition. cDNAs were cotransfected with a CMV or a SV40 driven Renilla vector. The candidates were considered positive when they significantly activated or repressed the reported activity compared to their reference values at least at one of the doses in both assays. Their effects are represented with green or red arrow respectively. Gray arrows represent candidates that did not display significant changes in luciferase activity at the doses tested in this study but whose reference values were significantly higher (putative activator) or lower (putative repressor) than the average of the remaining clones.