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(−)-Maackiain binds to Hsp90 and disrupts Hsp90-PKCδ interaction. A and B, pull-down assay. Whole cell extracts were incubated with (−)-maackiain-immobilized beads (A) or ATP-immobilized agarose (B), and Hsp90 was detected by immunoblot analysis (IB). C, immunoprecipitation assay (IP). The extracts were immunoprecipitated with a PKCδ antibody, and Hsp90 was detected by immunoblot analysis.
