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Efficacy and potency of GHS-R1a ligands to trigger activation of Gq, Gi, and Go. The BRET signal was recorded as a function of increasing concentrations of ligands in HEK293T cells co-expressing GHS-R1a and the G protein sensors. The effect of JMV 2959, JMV 3002, JMV 3018, and JMV 3011 was tested only on Gq, Gi2, and Gob. Data are representative of three independent experiments each performed in triplicate. Values of EC50 and Emax are reported in Table 2.
