TABLE 2.

Potencies and maximal efficacies of GHS-R1a ligands

EC₅₀ and E_max values were determined from dose-response curves performed in HEK293T cells expressing GHS-R1a as described under “Experimental Procedures.” For the agonist and neutral compounds, E_max is expressed as the percentage of maximal ghrelin. For the inverse agonists compounds, E_max is expressed as the maximal basal inhibition (100% inhibition corresponding to the basal of mock-transfected HEK293T cells). Values are mean ± S.E. of three independent experiments performed in triplicate. ND, not determined; NC, cannot be determined.