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. 2015 Sep 11;290(45):26943–26953. doi: 10.1074/jbc.M115.682138

FIGURE 1.

FIGURE 1.

Schematic view of the interacting domains within the IL-6 hexameric signaling complex. IL-6 interacts with D2 and D3 of IL-6R (site I). Within this dimer, IL-6 and IL-6R are both involved in binding to D2 and D3 of gp130 through sites IIa and IIb, respectively. Additional interactions form the IL-6 signaling hexameric complex by assembling two dimers (i and ii) of IL-6·IL-6R·gp130 through D1 of gp130 (sites IIIa and IIIb). IL-6 is in white, IL-6R is in light gray, and gp130 is in dark gray.