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Model to illustrate the potential mechanism of action of 25F10. 25F10 inhibits the hexamer assembly when bound to mb- and sIL-6R (red lines). Nevertheless, the IL-6·mbIL-6R·25F10·gp130 complex may be considered as an intermediary step to induce cis-signaling, whereas hexamer formation would be sufficient and necessary for trans-signaling.
