FIGURE 5.

Selected plots from simulations. A, concentrations of mitochondrial iron species under anaerobic growth conditions assuming the Dual-Reg variant. In the diseased state, [FM] is ∼20-fold higher than [MP]. B, [F3] (dashed purple line, right axis) simulated by the C-Reg variant does not decline in the diseased state. [C] (green line, left axis) simulated by the FS-Reg variant increases to unrealistically high concentrations in the diseased state. C, import rates simulated by the C-Reg variant are invarient in the diseased state: no accumulation of iron in mitochondria. D, simulation of [F2] and [F3] by the Dual-Reg variant in CCC1-UP cells that are adenine-deficient. [F2] is subtantially higher than [F3] as observed.