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. Author manuscript; available in PMC: 2016 Apr 17.
Published in final edited form as: ACS Chem Biol. 2015 Feb 9;10(4):978–988. doi: 10.1021/cb5009487

Table 1.

TCM Citations, Targets, and Activities

Compound Structure Representative molecular targets
and EC50 values (μM)		 Pubmed
citationsa
Curcumin graphic file with name nihms-735741-t0007.jpg Ca2+-ATPase (~3),
HER2, HIV-1 (100) and HIV-2
protease (250), cyclooxygenase
(52), PkAand PkC		 6394
Kaempferol graphic file with name nihms-735741-t0008.jpg ERR, OATP1B1, CDK (2.5 -51)
and trypsin (60, 106)		 2960
Physcion graphic file with name nihms-735741-t0009.jpg PTP1B (20), MMP (26.8 – 45.3) 244
Silibinin graphic file with name nihms-735741-t0010.jpg Hsp90 (250), GLUT4 (60) 957
Emodin graphic file with name nihms-735741-t0011.jpg MMP (12.8-20.1), AMPK (0.5), 11
β HSD1(4.2-7.2), trypsin (50),
DYRK1A and CLK1 (4.2 – 6.1)		 1302
Diphyllin graphic file with name nihms-735741-t0012.jpg Protective antigen’
DNA topoisomerase II		 40
Bufalin graphic file with name nihms-735741-t0013.jpg P-glycoprotein (100),
CYP3A4 (14.5)		 272
Brazilin graphic file with name nihms-735741-t0014.jpg PKC 66
Puerarin graphic file with name nihms-735741-t0015.jpg IK1, ASICs (38.4) 719
Delphinidin graphic file with name nihms-735741-t0016.jpg Histone acetyltransferase,
GL01 (1.9)		 550
Equol graphic file with name nihms-735741-t0017.jpg ERR (5.8), ERRD 790
Canadine graphic file with name nihms-735741-t0018.jpg Coagulation factor III, CDK2(>50) 76
Phlorizin graphic file with name nihms-735741-t0019.jpg SGLT1 and SGLT2 (0.02),
hCNT (100-200)		 2341
Noscapine graphic file with name nihms-735741-t0020.jpg OCT2 (2.6), tubulin,
MATE1 (34.5)		 423
a

As of 2/26/14.