Table 3.
Inhibition of TCM Targets Can Be Reversed by Nonionic Detergent
| IC50 vs trypsin (μM) |
IC50 vs HIV-2 protease (μM) |
|||
|---|---|---|---|---|
| compound | no detergenta |
with detergentb |
no detergentc |
with detergentd |
| emodin | 49 | >500 | ||
| kaempferol | 110 | >250 | ||
| curcumin | 19 | >100 | ||
a
50 mM potassium phosphate, pH 7.0.
b
50 mM potassium phosphate, pH 7.0 + 0.01% (v/v) Triton X-100.
c
50 mM sodium acetate, pH 5.5, 200 mM sodium chloride, 1 mM EDTA and 0.5 mM TCEP.
d
50 mM sodium acetate, pH 5.5, 200 mM sodium chloride, 1 mM EDTA and 0.5 mM TCEP + 0.01% (v/v) Triton X-100.