Table 2.
PAX2 Loss in Cases of Histologically Normal and Abnormal Endometrial Tissue using WHO Diagnostic Categories
| Percent PAX2 Loss | |||||
|---|---|---|---|---|---|
| Diagnostic Category | No/Minimal Loss | Partial Loss | Complete Loss | ||
| N | n (%) | n (%) | n (%) | P 2 | |
| Proliferative | 18 | 14 (77.8) | 4 (22.2) | 0 (0.0) | reference |
| Secretory | 10 | 9 (90.0) | 1 (10.0) | 0 (0.0) | 0.63 |
| Simple Hyperplasia | 23 | 8 (34.8) | 11 (47.8) | 4 (17.4) | 0.01 |
| Complex Hyperplasia1 | 84 | 7 (8.4) | 27 (32.5) | 49 (59.0) | <0.001 |
| Atypical Hyperplasia1 | 56 | 2 (3.7) | 12 (22.2) | 40 (74.1) | <0.001 |
| FIGO Grade 1 | |||||
| Endometrioid cancer | 15 | 1 (6.7) | 3 (20.0) | 11 (73.3) | <0.001 |
Abbreviations: WHO=World Health Organization; PAX2=Paired Box 2 gene; FIGO 1=International Federation of Gynecology and Obstetrics Grade 1
1
PAX2 data missing for 1 woman with complex hyperplasia and 2 women with atypical hyperplasia.
2
Fisher's Exact test used to calculate P values.