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. 2015 Nov 11;10:6997–7018. doi: 10.2147/IJN.S86592

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© 2015 Chen et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Detection of tumors by MRI in nude mice implanted with HT29 cells ex vivo labeled with USPIO-CD133 Ab.

Notes: (A) On day 14 after subcutaneous injection of HT29 cells without (Ai and Aii) or with ex vivo labeling of USPIO-CD133 Ab (Aiii and Aiv), xenografted tumors were noted at both flanks (arrows) and scanned by MRI for FSE T2-weighted (Ai and Aiii) and Merge (Aii and Aiv) images. (B) The representative signal ratio of tumor/muscle in MR images, including FSE T2-weighted (Bi) and Merge images (Bii). Bar, SE; *P<0.05.

Abbreviations: FSE, fast spin echo; MRI, magnetic resonance imgaing; Merge, multiple echo recombined gradient echo; SE, standard error of the mean; USPIO-CD133 Ab, ultrasmall superparamagnetic iron oxide conjugated with anti-CD133 antibodies.