Table 2. Association between IL33-IL1RL1 polymorphisms and cIMT values in RA patients.
| IL33 SNP | Genotype/Allele | cIMT mm | p | P* | IL1RL1 SNP | Genotype/Allele | cIMT mm | p | P* |
|---|---|---|---|---|---|---|---|---|---|
| mean ± SD (n) | mean ± SD (n) | ||||||||
| rs3939286 | CC | 0.76 ± 0.16 (258) | 0.10 | 0.006 | rs2058660 | AA | 0.74 ± 0.17 (325) | 0.91 | 0.58 |
| CT | 0.73 ± 0.17 (259) | AG | 0.73 ± 0.18 (213) | ||||||
| TT | 0.71 ± 0.14 (50) | GG | 0.75 ± 0.16 (36) | ||||||
| C | 0.75 ± 0.18 (775) | 0.04 | 0.0023 | A | 0.74 ± 0.17 (863) | 0.95 | 0.40 | ||
| T | 0.72 ± 0.16 (359) | G | 0.74 ± 0.18 (285) | ||||||
| rs7025417 | TT | 0.75 ± 0.18 (372) | 0.15 | 0.16 | rs2310173 | GG | 0.74 ± 0.17 (154) | 0.93 | 0.76 |
| TC | 0.72 ± 0.17 (172) | GT | 0.74 ± 0.18 (280) | ||||||
| CC | 0.76 ± 0.20 (21) | TT | 0.74 ± 0.18 (142) | ||||||
| T | 0.74 ± 0.18 (916) | 0.23 | 0.16 | G | 0.74 ± 0.17 (588) | 0.77 | 0.45 | ||
| C | 0.73 ± 0.17 (214) | T | 0.74 ± 0.18 (564) | ||||||
| rs7044343 | TT | 0.73 ± 0.17 (280) | 0.35 | 0.33 | rs13015714 | TT | 0.74 ± 0.18 (322) | 0.88 | 0.39 |
| TC | 0.74 ± 0.17 (229) | TG | 0.73 ± 0.18 (215) | ||||||
| CC | 0.77 ± 0.20 (54) | GG | 0.74 ± 0.17 (37) | ||||||
| T | 0.73 ± 0.17 (789) | 0.20 | 0.26 | T | 0.74 ± 0.18 (859) | 0.73 | 0.29 | ||
| C | 0.75 ± 0.18 (337) | G | 0.73 ± 0.18 (289) |
cIMT: carotid intima-media thickness; RA: Rheumatoid arthritis; SNP: Single nucleotide polymorphism; SD: Standard deviation. Significant results are highlighted on bold.
*p-value after adjusting for sex, age at the time of ultrasonography study, follow-up time and center.