Fig 1. Daily NEL (Mcal) intake, weekly body weight, temporal concentrations of serum 2,4-Thiazolidinedione (–7 to 42 d), and temporal concentrations (–7 to 14 d relative to diet initiation; before TZD administration) of serum NEFA, insulin and adiponectin in cows fed either a low-energy diet (CON, 1.30 Mcal/kg; n = 7) or high-energy diet (OVE, 1.60 Mcal/kg; n = 7) before, during (i.e. gray area) and after (washout) TZD administration.

Significant differences between diet, day and diet × day (Int., P ≤ 0.05) are denoted with ** or a,b.