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. Author manuscript; available in PMC: 2015 Nov 16.
Published in final edited form as: Antivir Ther. 2007;12(4):431–451.

Figure 1. HPV life cycle and structure of the viral genome.

Figure 1

(A) Schematic representation of the human papillomavirus (HPV) life cycle within a differentiating epithelium. The different epithelial strata are indicated on the left. The diagram at the centre represents a prototypical infected keratinocyte undergoing terminal differentiation and harbouring viral episomes within its nucleus. Specific viral life cycle events occurring in each stratum are summarized on the right. (B) The genome of HPV16 is diagrammed in linear form. The coding regions of the early and late viral proteins are indicated by open boxes. Proteins that have been validated as potential antiviral targets are dark grey. The L1 protein, which has been shown to be a valid target for a microbicide, is light grey. The long-control region (LCR), which contains the transcriptional enhancer and promoter regions as well as the origin of DNA replication, is indicated by a two-way arrow.