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. Author manuscript; available in PMC: 2016 Nov 1.
Published in final edited form as: J Magn Reson. 2015 Aug 18;260:144–160. doi: 10.1016/j.jmr.2015.07.014

Fig. 13.

Fig. 13

Reaction schemes for chemical derivatization using 13C, 15N or 31P tags to target amine, carboxylic acid or alcohol metabolites in complex biological mixtures to enable NMR detection with enhanced resolution and sensitivity [modified from Refs. [72,74,75]].