Skip to main content
. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Am J Surg Pathol. 2015 Dec;39(12):1730–1741. doi: 10.1097/PAS.0000000000000533

Figure 7.

Figure 7

Acinar-ductal metaplasia (ADM) and the atypical flat lesion (AFL) in the human pancreas. AC: ADM presents as an intralobular change characterized by progressive replacement of acini by ductular structures, which might display intracytoplasmic mucin, thereby resembling low-grade PanIN. Arrows indicate hybrid ductuli with co-expression of trypsin (B) and CK7 (C). Scale bars: 200μm. D–F: AFL are intralobular ductular proliferations with cytological atypia surrounded by a loose matrix with inflammatory infiltrates. AFL are located in ADM areas and may show focally retained tryspin expression (E), but mostly display a ductal phenotype with strong and diffuse CK7 staining (F). Scale bars: 200μm.