Table 2.
Effect modifiers influencing blood pressure trajectory level within each group: univariate and multivariable analyses, age 7 to 38 years
| Univariate | Multivariable* | |||||
|---|---|---|---|---|---|---|
| Risk factor | Shift in trajectory per unit change in variable | 95% CI | p-value | Shift in trajectory per unit change in variable | 95% CI | p-value |
| Body mass index | ||||||
| Normal group | 0.53 | 0.41, 0.65 | <.001 | 0.50 | 0.36, 0.63 | <.001 |
| High-normal group | 0.92 | 0.78, 1.05 | <.001 | 0.79 | 0.67, 0.91 | <.001 |
| Prehypertensive group | 1.09 | 0.94, 1.24 | <.001 | 1.04 | 0.89, 1.18 | <.001 |
| Hypertensive group | 1.62 | 1.18, 2.07 | <.001 | 1.70 | 1.25, 2.15 | <.001 |
| Average weekly alcohol consumption | ||||||
| Normal group | 0.02 | −0.03, 0.07 | .49 | 0.01 | −0.06, 0.08 | .72 |
| High-normal group | 0.08 | 0.03, 0.13 | .002 | 0.02 | −0.03, 0.06 | .47 |
| Prehypertensive group | −0.04 | −0.10, 0.03 | .30 | −0.02 | −0.06, 0.03 | .49 |
| Hypertensive group | 0.00 | −0.11, 0.11 | .98 | 0.06 | −0.11, 0.23 | .47 |
| Number of cigarette per day (in last month) | ||||||
| Normal group | 0.05 | −0.05, 0.15 | .33 | 0.07 | −0.04, 0.18 | .19 |
| High-normal group | 0.11 | 0.03, 0.19 | .007 | 0.07 | 0.00, 0.15 | .05 |
| Prehypertensive group | 0.01 | −0.08, 0.11 | .83 | 0.09 | 0.01, 0.17 | .02 |
| Hypertensive group | 0.05 | −0.11, 0.22 | .52 | 0.23 | −0.07, 0.53 | .13 |
Model contains early life factors (maternal hypertension, birthweight, birth order, gender, family history of high blood pressure, breastfeeding, early childhood socioeconomic status) and effect modifiers (body mass index, alcohol consumption, cigarette smoking)