Fig. 3. Effect of increasing doses of pNaKtide on body weight in mice fed a high-fat diet.

Treatment with pNaKtide at doses of 1 and 5 mg/kg did not significantly reduce body weight in C57Bl6 mice fed a high-fat diet. However, administration of pNaKtide at 25 mg/kg every 8 days in mice fed a high-fat diet for 8 weeks significantly reduced body weight as compared to high-fat diet–fed animals. There were no significant changes in food intake among the groups. Results are means ± SE, n = 7 to 14 per group; *P < 0.05 versus control, ^#P < 0.05 versus high-fat diet.