Table 4.
Comparison | Hepatitis C health states | TTO with 10-year time horizon | TTO with 1-year time horizon | ||||
---|---|---|---|---|---|---|---|
Mean utilitya | Mean (SD) difference score | P valueb | Mean utilitya | Mean (SD) difference score | P valueb | ||
A vs B | A. 1 tablet per day | 0.80 | 0.00 (0.01) | 0.32 | 0.81 | 0.00 (0.01) | 0.32 |
B. 2 tablets per day | 0.80 | 0.81 | |||||
A vs C | A. 1 tablet per day | 0.80 | 0.00 (0.02) | 0.059 | 0.81 | 0.00 (0.02) | 0.041 |
C. 3 tablets per day | 0.79 | 0.80 | |||||
A vs D | A. 1 tablet per day | 0.80 | 0.01 (0.04) | 0.0036 | 0.81 | 0.01 (0.06) | 0.0032 |
D. 7 tablets per day | 0.79 | 0.79 | |||||
B vs C | B. 2 tablets per day | 0.80 | 0.00 (0.01) | 0.045 | 0.81 | 0.00 (0.02) | 0.071 |
C. 3 tablets per day | 0.79 | 0.80 | |||||
B vs D | B. 2 tablets per day | 0.80 | 0.01 (0.03) | 0.0026 | 0.81 | 0.01 (0.06) | 0.0043 |
D. 7 tablets per day | 0.79 | 0.79 | |||||
C vs D | C. 3 tablets per day | 0.79 | 0.01 (0.03) | 0.0036 | 0.80 | 0.01 (0.05) | 0.0068 |
D. 7 tablets per day | 0.79 | 0.79 | |||||
D vs E | D. 7 tablets per day | 0.79 | 0.02 (0.05) | <0.0001 | 0.79 | 0.02 (0.07) | 0.0002 |
E. 7 tablets per day + weekly injection | 0.77 | 0.77 | |||||
E vs F | E. 7 tablets per day + weekly injection | 0.77 | 0.02 (0.06) | 0.0002 | 0.77 | 0.02 (0.07) | 0.0005 |
F. 12 tablets per day + weekly injection | 0.75 | 0.76 | |||||
E vs H | E. 7 tablets per day + weekly injection | 0.77 | 0.07 (0.16) | <0.0001 | 0.77 | 0.05 (0.13) | <0.0001 |
H. 18 tablets per day + weekly injection | 0.71 | 0.72 | |||||
F vs H | F. 12 tablets per day + weekly injection | 0.75 | 0.05 (0.13) | <0.0001 | 0.76 | 0.04 (0.09) | <0.0001 |
H. 18 tablets per day + weekly injection | 0.71 | 0.72 | |||||
F vs G | F. 12 tablets per day + weekly injection | 0.75 | 0.04 (0.16) | 0.0005 | 0.76 | 0.04 (0.17) | 0.0024 |
G. 12 tablets per day (taken with fatty food) + weekly injection | 0.71 | 0.72 |
aTTO scores are on a scale anchored with 0 representing dead and 1 representing full health
b P values are based on t tests comparing two utility means