Fig. 2.

Balance between a distinct subset of AKAPs important for disease development. Expression of AKAP12 is decreased in various cancers and COPD. In cancers, Ezrin switched from an anti-proliferative to a pro-proliferative function. Cigarette smoke induced reduction of AKAP12 and elevation of Ezrin in airway smooth muscle might represent a common link between cancer and CODP. For further details and references, see text