Table 1.
BMI and genotype frequencies for single-minded 1 (SIM1) Ala371Val (rs3734355) in severely obese cases and lean controls
| Genotype |
|||||
|---|---|---|---|---|---|
| Ala/Ala |
Ala/Val |
Val/Val |
|||
| BMI (kg/m2) (n) | BMI (kg/m2) (n) | BMI (kg/m2) (n) | P | Freq (Val) | |
| All casesa | 48.9 ± 0.6 (297) | 47.5 ± 0.8 (98) | 51.6 ± 3.0 (14) | NS | 0.15 |
| Male cases | 48.5 ± 1.1 (83) | 44.5 ± 1.1 (26) | 54.2 ± 7.4 (2) | 0.036 | 0.14 |
| Female cases | 49.0 ± 0.7 (214) | 48.6 ± 0.9 (72) | 51.2 ± 3.4 (12) | NS | 0.16 |
| All controlsb | 22.9 ± 0.1 (379) | 23.0 ± 0.1 (166) | 22.6 ± 0.4 (19) | NS | 0.18 |
| Male controls | 23.3 ± 0.1 (126) | 23.3 ± 0.1 (47) | 23.4 ± 0.4 (8) | NS | 0.17 |
| Female controls | 22.7 ± 0.1 (253) | 22.8 ± 0.1 (119) | 22.1 ± 0.5 (11) | NS | 0.18 |
a
Cases had a BMI ±40 kg/m2 and were obtained from an ongoing study at UCSF (13). BMI is shown as mean ± s.e.m.
b
Sex- and age-matched lean controls (BMI ≤25 kg/m2) were obtained from the same study.