Table 3.

Replicated SIM1 nsSNP association results in white subjects from the Health ABC Study

Dependent variable per SNPa	Whites (n = 1,613–1,711)b		White males (n = 854–907)b		White females (n = 759–804)b
	β ± s.e.	P	β ± s.e.	P	β ± s.e.	P
rs3734355
BMI (kg/m2)	1.31 ± 0.67	0.05	2.69 ± 0.91	0.003	0.29 ± 0.99	NS
% Body fat	1.71 ± 0.87	0.05	2.42 ± 1.20	0.04	1.08 ± 1.26	NS
Leptin (ng/ml)	0.35 ± 0.21	NS	0.47 ± 0.26	NS	0.26 ± 0.34	NS
Leptin (ng/ml)c	0.06 ± 0.16	NS	0.03 ± 0.20	NS	0.11 ± 0.24	NS
VAT (cm2)	0.46 ± 0.33	NS	0.16 ± 0.50	NS	0.78 ± 0.42	NS
SAT (cm2)	–0.09 ± 0.27	NS	0.03 ± 0.38	NS	–0.06 ± 0.37	NS

NS, nonsignificant; SAT, abdominal subcutaneous adipose tissue; SIM1, single-minded 1; nsSNP, nonsynonymous single-nucleotide polymorphism; VAT, abdominal visceral adipose tissue.

^ars3734355 was studied assuming a recessive mode of inheritance.

^bSample size range for 6 models, sample sizes for each model are found in Supplementary Table S2 online.

^cLeptin outcome was adjusted for percentage of body fat.