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. 2015 Nov 17;5:16411. doi: 10.1038/srep16411

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Bold-solid lined box: SP is converted to 6-hydroxy-3-succinoyl-pyridine (HSP) by SP monoxygenase (SpmABC) in P. putida S16²⁵. Solid lined box: (1) The hypotensive agent derived from SP, ω-heteroaroyl-(propionyl)-L-prolines²⁰. (2) Analgesics derived from SP or HSP, propiram and epibatidine¹⁷,¹⁸. (3) Bioactivity pyridine derivative: vitamin B6 (pyridoxine)¹⁹. (4) Typical pyridine drugs: anti-inflammaroty drugs (clonixin, nicoboxil) and, (5) analeptics (nicethamide, camphotamide (dash line box))¹⁸.