Table 2.

Prediction models for pre-eclampsia at different gestational ages in Avon Longitudinal Study of Parents and Children (ALSPAC) and Southampton Women’s Survey (SWS) using imputed datasets. Figures are area under receiver operating characteristic curve (95% confidence intervals)

Gestational age of prediction (weeks)	Development cohort (ALSPAC)				Validation cohort (SWS)
	Model 1*	Model 2†	P value for 2 v 1		Model 1*	Model 2†	P value for 2 v 1
20	0.77 (0.75 to 0.80)	0.79 (0.77 to 0.82)	0.002		0.79 (0.73 to 0.85)	0.80 (0.74 to 0.85)	0.47
25	0.77 (0.75 to 0.80)	0.80 (0.77 to 0.82)	<0.001		0.79 (0.73 to 0.85)	0.80 (0.75 to 0.86)	0.39
28	0.77 (0.75 to 0.80)	0.81 (0.79 to 0.84)	<0.001		0.79 (0.73 to 0.85)	0.84 (0.79 to 0.88)	0.003
31	0.77 (0.74 to 0.79)	0.82 (0.80 to 0.85)	<0.001		0.79 (0.73 to 0.85)	0.84 (0.79 to 0.89)	0.008
34	0.77 (0.74 to 0.80)	0.84 (0.82 to 0.87)	<0.001		0.81 (0.75 to 0.87)	0.86 (0.81 to 0.90)	0.01
36	0.77 (0.74 to 0.80)	0.88 (0.86 to 0.90)	<0.001		0.80 (0.74 to 0.87)	0.88 (0.84 to 0.93)	<0.001

*Includes maternal covariates and mean arterial pressure at first visit.

†As model 1 plus observed value of mean arterial pressure for gestational age.