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. 2015 Nov 1;142(21):3734–3745. doi: 10.1242/dev.125328

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© 2015. Published by The Company of Biologists Ltd

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Fig. 2. — Wnt1-Cre;Erk2^fl/fl mice exhibit severe craniofacial malformations. (A-D) Sagittal (A,B) and ventral (C,D) views of newborn control and Wnt1-Cre;Erk2^fl/fl heads. (E-H) Intraoral views of the palates (E,F) and tongues (G,H) of control and Wnt1-Cre;Erk2^fl/fl newborns. (I,J) HE staining of sagittal sections of control and Wnt1-Cre;Erk2^fl/fl newborn tongues. (K,L) Myosin heavy chain (MHC; green) immunostaining of coronal sections of control and Wnt1-Cre;Erk2^fl/fl newborn heads. Dashed lines delineate the malformed and unfused palatal shelves in Wnt1-Cre;Erk2^fl/fl mice. (M-Q) 3D reconstructions of control and Wnt1-Cre;Erk2^fl/fl tongues from microCT scans. Tongue volumes of control and Wnt1-Cre;Erk2^fl/fl (Erk2 CKO) samples are quantified in Q. *P<0.05. n=3.