Table 2. Univariate and multivariate analyses of prognostic factors associated with (a) overall survival and (b) disease-free survival in patients with ductal carcinoma of the pancreas.
|
Univariate analysis |
Multivariate analysis |
|||
|---|---|---|---|---|
| Variables | HR (95% CI) | P-value | HR (95% CI) | P-value |
|
(a) Overall survival | ||||
| Age (<60 years/≥60 years) | 1.054 (0.802–1.386) | 0.707 | ||
| Gender (female/male) | 0.936 (0.712–1.230) | 0.634 | ||
| Tumour size (<30 mm/≥30 mm) | 1.884 (1.326–2.565) | 0.0003 | 1.303 (0.918–1.849) | 0.138 |
| Pathologic tumour status (T1+T2/T3) | 6.265 (1.555–25.377) | 0.010 | ||
| Pathologic node status (N0/N1) | 1.967 (1.349–2.868) | 0.0004 | 1.506 (1.018–2.2277) | 0.041 |
| Pathologic metastasis status (M0/M1) | 2.070 (1.416–3.025) | 0.0002 | 1.745 (1.179–2.583) | 0.005 |
| Histological grade (W/D/M/D, P/D)a | 1.439 (1.075–1.927) | 0.015 | 1.379 (1.022–1.862) | 0.036 |
| Tumour margin status (negative/positive) | 1.414 (1.062–1.883) | 0.018 | 1.188 (0.881–1.601) | 0.257 |
| Nerve plexus invasion (absence/presence)a | 1.485 (1.105–1.995) | 0.009 | 1.023 (0.737–1.421) | 0.891 |
| Lymphatic invasion (0, 1/2, 3)a | 2.163 (1.574–2.970) | <0.0001 | 1.643 (1.177–2.292) | 0.004 |
| Venous invasion (0, 1/2, 3)a | 1.926 (1.446–2.565) | <0.0001 | 1.301 (0.955–1.772) | 0.095 |
| Intrapancreatic neural invasion (0, 1/2, 3)a | 1.814 (1.373–2.397) | <0.0001 | 1.671 (1.256–2.223) | 0.0004 |
| Intratumoral TLOs (presence/absence) | 1.800 (1.234–2.624) | 0.002 | 1.637 (1.115–2.403) | 0.012 |
|
(b) Disease-free survival | ||||
| Age (<60 years/≥60 years) | 1.148 (0.868–1.523) | 0.339 | ||
| Gender (female/male) | 0.974 (0.732–1.297) | 0.858 | ||
| Tumour size (<30 mm/≥30 mm) | 1.911 (1.353–2.699) | 0.0002 | 1.340 (0.926–1.939) | 0.120 |
| Pathologic tumour status (T1+T2/T3) | 3.881 (1.239–12.154) | 0.020 | 1.701 (0.518–5.584) | 0.376 |
| Pathologic node status (N0/N1) | 1.985 (1.344–2.932) | 0.0006 | 1.465 (0.977–2.196) | 0.063 |
| Pathologic metastasis status (M0/M1) | 2.473 (1.659–3.686) | <0.0001 | 2.091 (1.388–3.152) | 0.0004 |
| Histological grade (W/D/M/D, P/D)a | 1.435 (1.061–1.942) | 0.019 | 1.245 (0.910–1.703) | 0.171 |
| Tumour margin status (negative/positive) | 1.343 (0.995–1.811) | 0.054 | ||
| Nerve plexus invasion (absence/presence)a | 1.367 (1.010–1.852) | 0.043 | 1.042 (0.744–1.459) | 0.811 |
| Lymphatic invasion (0, 1/2, 3)a | 2.138 (1.533–2.980) | <0.0001 | 1.591 (1.112–2.277) | 0.011 |
| Venous invasion (0, 1/2, 3)a | 1.917 (1.430–2.571) | <0.0001 | 1.442 (1.057–1.969) | 0.021 |
| Intrapancreatic neural invasion (0, 1/2, 3)a | 1.594 (1.194–2.128) | 0.002 | 1.377 (1.024–1.851) | 0.034 |
| Intratumoral TLOs (presence/absence) | 1.775 (1.209–2.607) | 0.003 | 1.611 (1.092–2.375) | 0.016 |
Abbreviations: M/D=moderately differentiated tubular adenocarcinoma; P/D=poorly differentiated adenocarcinoma; W/D=well differentiated tubular adenocarcinoma and papillary carcinoma. P-values of univariate analysis of overall survival and pathological tumour status (T1+T2/T3) are shown in bold.
a
Classified according to the classification of pancreatic carcinoma of Japan Pancreas Society.