It takes Zeb2 to tango: Cooperation between T-bet and Zeb2 is essential for CD8⁺ T cell effector differentiation and NK cell development. Although increasing T-bet expression alone can mediate some of the necessary gene expression changes, coordination with Zeb2 (which is itself under T-bet transcriptional control) is required for full commitment and expansion of terminally differentiated CD8⁺ T cells and mature NK cells.