Table 1.
Baseline characteristics of adult residents with and without incident CHD during follow-up in the Vara-Skövde cohort
| Men | Women | |||||||
|---|---|---|---|---|---|---|---|---|
| All N = 1350 | No CHD N = 1298 | CHD N = 52 | P-value | All N = 1395 | No CHD N = 1375 | CHD N = 20 | P-value | |
| Mean ± SD | Mean ± SD | |||||||
| Age (yrs) | 47.3±11 | 46.7 ± 11 | 61.2±11 | <0.001 | 47.7±12 | 47.4±12 | 63.9±11 | <0.001 |
| WHR | 0.9±0.1 | 0.9±0.1 | 1.0±0.1 | <0.001 | 0.8±0.1 | 0.8±0.1 | 0.9±0.1 | 0.004 |
| BMI (kg/m2) | 26.9±4 | 26.8±4 | 27.4±3 | 0.200 | 26.8±5 | 26.8±5 | 27.8±4 | 0.661 |
| HOMA-IR | 1.6±1.3 | 1.6±1.3 | 2.4±1.8 | <0.001 | 1.5±1.6 | 1.5±1.6 | 2.1±1.7 | 0.073 |
| S-LDL (mmol/l) | 3.4 ± 0.9 | 3.4 ± 0.9 | 3.9 ± 0.9 | <0.001 | 3.2 ± 0.9 | 3.1 ± 0.9 | 3.8 ± 1.1 | 0.001 |
| S-HDL (mmol/l) | 1.2 ± 0.3 | 1.2 ± 0.3 | 1.2 ± 0.3 | 0.916 | 1.4 ± 0.3 | 1.4 ± 0.3 | 1.3 ± 0.4 | 0.164 |
| S-Cholesterol (mmol/l) | 5.4 ± 1 | 5.4 ± 1 | 5.7 ± 1 | 0.018 | 5.3 ± 1.1 | 5.2 ± 1 | 5.4 ± 1.2 | 0.331 |
| ApoB/apoA1 | 0.6 ± 0.2 | 0.6 ± 0.2 | 0.7 ± 0.2 | 0.002 | 0.5 ± 0.2 | 0.6 ± 0.2 | 0.7 ± 0.2 | 0.021 |
| S-Triglycerides (mmol/l) | 1.5 ± 0.9 | 1.4 ± 0.9 | 1.8 ± 1.1 | 0.018 | 1.1 ± 0.6 | 1.1 ± 0.6 | 1.4 ± 0.9 | 0.003 |
| Hs-CRP (mg/l) | 2.4 ± 5.8 | 2.2 ± 4.2 | 6.1 ± 21 | <0.001 | 2.8 ± 4.6 | 2.8 ± 4.6 | 3.2 ± 3.9 | 0.675 |
| Systolic blood pressure (mmHg) | 124 ± 16 | 123 ± 15 | 138 ± 19 | <0.001 | 119 ± 18 | 119 ± 18 | 143 ± 20 | <0.001 |
| Diastolic blood pressure (mmHg) | 72 ± 10 | 72 ± 10 | 78 ± 12 | <0.001 | 69 ± 10 | 68 ± 10 | 77 ± 10 | <0.001 |
| Alcohol consumption (g/week) | 62 ± 108 | 62 ± 108 | 55 ± 91 | 0.666 | 31 ± 43 | 31 ± 44 | 20 ± 36 | 0.278 |
| S-Testosterone (nmol/l) | 14 ± 4.3 | 14 ± 4.3 | 13 ± 4.7 | 0.147 | 1.3 ± 1.3 | 1.3 ± 1.3 | 1.1 ± 0.5 | 0.524 |
| S-Estradiol (nmol/l) | 125 ± 37 | 125 ± 37 | 126 ± 40 | 0.875 | 304±381 | 305 ± 383 | 221 ± 50 | 0.314 |
| N (%) | N (%) | |||||||
| Hypertension | 183 (14) | 165 (13) | 22 (42) | <0.001 | 204 (14) | 192 (14) | 12 (57) | <0.001 |
| Type 2 diabetes | 78 (5.7) | 66 (5) | 12 (23) | <0.001 | 65 (4.6) | 61 (4.4) | 4 (19) | 0.004 |
| Daily smoking | 214 (16) | 201 (15) | 13 (25) | 0.068 | 288 (21) | 282 (20) | 6 (29) | 0.364 |
| Low physical activity | 521 (38) | 500 (40) | 21 (45) | 0.742 | 384 (27) | 382 (29) | 2 (10) | 0.088 |
| Medication | ||||||||
| ARB | 14 (1.0) | 13 (1.0) | 1 (1.9) | 0.886 | 13 (0.9) | 13 (1.0) | 0 (0) | 0.999 |
| ASA | 31 (2.2) | 27 (2.1) | 4 (7.7) | 0.991 | 34 (2.4) | 31 (2.2) | 3 (14) | 0.426 |
| Statin | 25 (1.8) | 22 (1.7) | 3 (5.8) | 0.673 | 42 (2.9) | 38 (2.7) | 4 (19) | 0.247 |
| β-Blocker | 64 (4.7) | 58 (4.4) | 6 (11.5) | 0.830 | 89 (6.3) | 80 (5.8) | 9 (43) | 0.007 |
| ACE inhibitor | 24 (1.8) | 21 (1.6) | 3 (5.8) | 0.716 | 29 (2) | 26 (1.9) | 3 (14) | 0.166 |
| Metformin | 14 (1.0) | 13 (1.0) | 1 (1.9) | 0.992 | 19 (1.3) | 18 (1.3) | 1 (4.8) | 0.988 |
| HRT | - | - | - | - | 247 (17) | 238 (17) | 9 (43) | 0.434 |
All means are adjusted
All means are adjusted for differences in age. CHD: coronary heart disease; WHR: waist hip ratio (missing 10/2745); BMI: body mass index (missing 3/2745); HOMA-IR: homeostatic model assessment of insulin resistance (missing 39/2745); LDL: low-density lipoprotein (missing 2/2745); HDL: high-density lipoprotein (missing 2/2745); ApoB/apoA1: apolipoprotein B/apolipoprotein A1 (missing 4/2745), hs-CRP: high sensitivity c-reactive protein (missing 2/2745); testosterone (missing 135/2745); estradiol (missing 30/2745); type 2 diabetes (missing 2/2745); physical activity (missing 91/2745); ARB: angiotensin II receptor blockers; ASA: acetyl-salicylic acid; ACE inhibitors: angiotensin converting enzyme inhibitor; HRT: hormone replacement therapy. 12 g alcohol is equivalent to approximately 1 glass of wine (12–15 cl) or 1 small beer (33 cl) (missing 126/2745). Differences in continuous variables were investigated using general linear models. Differences in dichotomous variables were analysed using logistic regression analyses