Fig. 1.

Network of Gonadal Sex Determination leading to Sertoli or granulosa cell fate commitment and differentiation. The network was inferred from reviewed experimental evidence of genes associated within the process and structured according to developmental stages in: urogenital ridge (UGR node), bipotential gonadal primordium (yellow nodes), male pathway of sex determination (blue nodes), female pathway of sex determination (pink nodes). Nodes represent genes; arrow lines denote activation; bar head lines indicate inhibition; black, blue and, pink solid lines represent validated interactions in human; green solid lines represent interactions validated in mouse; punctuated lines in orange represent model predictions