Fig. 4.

Modeling 46,XX sex reversal. The SRY node was kept as active (1) so as to simulate traslocation in a 46,XX background. SRY activates SOX9 in combination with CBX2, GATA4, WT1 and NR5A1. Then, SOX9 activates nodes associated with the male pathway (i.e., FGF9, PGD2, DHH, AMH). The fixed point attractor can be interpreted as a 46,XX sex reversal after three time steps (a). The SOX9 node was set as active in order to simulate a duplication in a 46,XX background (b). The resulted activation states were similar to the observed in the male pathway. Thus, the fixed point attractor can be interpreted as a 46,XX sex reversal in absence of SRY, as reported in clinical cases