Fig. 5.

Modeling 46,XY sex reversal. The CBX2 node was inactivated in order to simulate a loss of function mutation in a 46,XY background which resulted in a steady state attractor that showed activation of female nodes (a). The NR0B1 node was set as active in order to simulate a duplication in a 46,XY background. The activation states were altered and resulted in an steady state attractor with activated female nodes (b). The SRY node was inactivated in order to simulate a loss of function mutation which resulted in a steady state attractor that showed activation of female nodes (c)