Table 2.
Effect of TVL on pre-treated (baseline) and post-treated (week 7) bodyweights, relative organ weights and food and water intake in rats during the experimental period
| Parameters | Experimental groups | ||||
|---|---|---|---|---|---|
| NDC | DC | D + TVL60 | D + TVL120 | D + glibenclamide | |
| Body weight (g) | |||||
| Pre-treated | 334.40 ± 17.82 | 281.30 ± 9.07* | 276.00 ± 10.54* | 284.10 ± 6.38* | 291.50 ± 15.20 |
| Post-treated | 411.00 ± 16.27a | 287.60 ± 8.88*** | 295.20 ± 11.52*** | 312.90 ± 8.29a*** | 312.60 ± 12.71*** |
| % HW | 0.27 ± 0.022 | 0.35 ± 0.01*** | 0.32 ± 0.01# | 0.30 ± 0.01# | 0.32 ± 0.01# |
| % LKW. | 0.25 ± 0.01 | 0.47 ± 0.01*** | 0.41 ± 0.01*** # | 0.38 ± 0.02*** # | 0.40 ± 0.01***# |
| % LLW | 1.21 ± 0.09 | 1.75 ± 0.03*** | 1.65 ± 0.03*** | 1.57 ± 0.04** # | 1.55 ± 0.06** # |
| Food intake (g/rat/day) | 16.00 ± 1.47 | 37.00 ± 2.03** | 34.75 ± 1.96** | 30.00 ± 3.30* | 36.67 ± 4.01** |
| Water intake (ml/rat/day) | 18.00 ± 3.74 | 158.00 ± 5.83*** | 132.90 ± 7.78***# | 111.70 ± 11.08***# | 121.70 ± 7.03***# |
Non-diabetic control (NDC) and diabetic control (DC); TVL 60 mg/kg.b.w.(D + TVL 60); TVL 120 mg/kg.b.w. (D + TVL 120) and glibenclamide 10 mg/kg.b.w. (D + glibenclamide. All data are expressed as mean ± SEM for 7 animals per group
aSignificantly different from pre-treated weight, p < 0.05
*Significantly different from NDC, p < 0.05
**Significantly different from NDC, p < 0.01
***Significantly different from NDC, p < 0.001
#Significantly different from DC, p < 0.05