Table 4.
Effect of TVL on serum lipids and liver enzymes in rats
| Parameters | Experimental groups | ||||
|---|---|---|---|---|---|
| NDC | DC | D + TVL 60 | D + TVL 120 | D + glibenclamide | |
| Triglycerides (mg/dl) | 92.00 ± 10.58 | 134.50 ± 7.09* | 100.70 ± 6.94# | 93.14 ± 10.00# | 93.50 ± 7.99# |
| Total cholesterol (mg/dl) | 73.00 ± 2.48 | 82.25 ± 1.80 | 74.80 ± 5.20# | 73.17 ± 4.45# | 67.67 ± 4.70# |
| HDL-cholesterol (mg/dl) | 24.40 ± 1.29 | 19.25 ± 0.75* | 26.00 ± 1.58# | 26.80 ± 1.86# | 20.33 ± 2.08 |
| LDL-cholesterol (mg/dl) | 30.30 ± 1.66 | 36.10 ± 3.17 | 28.00 ± 1.88 | 27.67 ± 2.84 | 28.47 ± 3.14 |
| VLDL (mg/dl) | 18.40 ± 1.64 | 26.90 ± 1.42* | 20.13 ± 1.39# | 18.63 ± 2.00# | 18.70 ± 1.60# |
| ALT (U/l) | 62.60 ± 4.40 | 120.80 ± 12.52*** | 78.50 ± 6.83*## | 77.75 ± 3.97* ## | 83.25 ± 3.82*# |
| AST (U/l) | 76.25 ± 1.25 | 98.00 ± 2.30* | 78.83 ± 2.32# | 79.83 ± 2.46# | 81.00 ± 2.58# |
Non-diabetic control (NDC) and diabetic control (DC); TVL 60 mg/kg.b.w., (D + TVL 60 mg/kg.b.w.TVL 120 mg/kg.b.w.(D + TVL 120) and glibenclamide 10 mg/kg.b.w.(D + glibenclamide). All data are expressed as mean ± SEM for 7 animals per group
*Significantly different from non-diabetic control p < 0.05
***Significantly different from non-diabetic control p < 0.001
#Significantly different from diabetic control p < 0.05
##Significantly different from diabetic control p < 0.01