Table 1.
Correlation of CD44s expression with demographics and histopathological findings in patients with ampullary adenocarcinoma who underwent resection
| Extent of CD44s expressiona | |||
|---|---|---|---|
| Negative or weak (< 25 %) | Moderate or dense (≥ 25 %) | P-value | |
| Patients, number (%) | 55 (56 %) | 43 (44 %) | |
| Age, y, mean (range) | 65 (32–90) | 65 (35–84) | 0.971 |
| Sex | 0.839 | ||
| Female | 26 (58 %) | 19 (42 %) | |
| Male | 29 (55 %) | 24 (45 %) | |
| Histology typeb | 0.139 | ||
| Intestinal | 26 (54 %) | 22 (46 %) | |
| Pancreaticobiliary | 19 (73 %) | 7 (27 %) | |
| Gross tumor type | 0.059 | ||
| Polypoid | 24 (45 %) | 29 (55 %) | |
| Ulcerative | 17 (71 %) | 7 (29 %) | |
| Mixed | 14 (67 %) | 7 (33 %) | |
| Tumor size, cm | 2.1 (0.7–8.0) | 2.2 (0.8–5.5) | 0.625 |
| Differentiationb | 0.904 | ||
| Well | 26 (58 %) | 19 (42 %) | |
| Moderate | 24 (59 %) | 17 (41 %) | |
| Poor | 4 (50 %) | 4 (50 %) | |
| Lymphovascular invasionb | 0.006 | ||
| Negative | 13 (39 %) | 20 (61 %) | |
| Positive | 24 (75 %) | 8 (25 %) | |
| Perineural invasionb | 0.558 | ||
| Negative | 19 (56 %) | 15 (44 %) | |
| Positive | 12 (67 %) | 6 (33 %) | |
| Resection margin | 0.167 | ||
| Free | 48 (55 %) | 40 (45 %) | |
| Microscopically positive | 7 (78 %) | 2 (22 %) | |
| Macroscopically positive | 0 | 1 (100 %) | |
| Pancreatic invasionb | 0.004 | ||
| Negative | 19 (40 %) | 29 (60 %) | |
| Positive | 34 (71 %) | 14 (29 %) | |
| Tumor stage | 0.034 | ||
| pT1 | 3 (33 %) | 6 (67 %) | |
| pT2 | 17 (44 %) | 22 (56 %) | |
| pT3 | 23 (68 %) | 11 (32 %) | |
| pT4 | 12 (75 %) | 4 (25 %) | |
| Lymph node metastasisb | 0.289 | ||
| pN0 | 30 (52 %) | 28 (48 %) | |
| pN1 | 23 (64 %) | 13 (36 %) | |
| AJCC TNM stage | 0.019 | ||
| Stage I | 16 (42 %) | 22 (58 %) | |
| Stage II | 27 (64 %) | 15 (36 %) | |
| Stage III | 12 (75 %) | 4 (25 %) | |
| Stage IV | 0 | 2 (100 %) | |
Abbreviations: AJCC TNM stage, American Joint Committee on Cancer tumor, node, metastases staging system
aAs determined by univariate analysis
bExcluding patients without detailed recorded