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. 2015 Nov 14;15:901. doi: 10.1186/s12885-015-1916-3

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© May et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Stable AXL knockdown in Lipo-246 cells significantly reduces tumor weight and volume. a AXL knockdown in Lipo-246 cells was evaluated by western blot prior to subcutaneous injection. b Tumor volume was monitored at the indicated time points. c Xenografts were weighed ex vivo following experiment termination. d Representative IHC images of Lipo-246 xenografts expressing NT control constructs or one of two AXL-targeting shRNAs are shown (400× magnification). Hematoxylin-eosin (H&E); cleaved caspase 3 (CC3). (* = p < 0.05; *** = p < 0.001)