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Trimodality therapy in sarcoma cells. Proliferation assay (A), colony formation assay (B), γH2AX expression (C) and cleaved caspase-3 expression in HT1080 and SK-LMS-1 human sarcoma cells and MS4515 and MS5907 mouse sarcoma cells after RT (8 Gy) and/or TH-302 (10 μM). All experiments were carried out in normoxia and hypoxia. Bars represent s.d. *P<0.05 compared with control. **P<0.05 compared with all other groups.
