Table 2. Multivariable analysis of the association between DFS or OS and miR-320e expression in stage II/III CRC patients, adjusting for tumour location and stage.
| Multivariate analysis |
Stage II and III |
||||
|---|---|---|---|---|---|
| Variable | Event/total | HR | 95% CI | P-value | c-index |
|
DFS | |||||
| miR-320e (per 0.0052 unitsa) | 60/167 | 1.39 | 1.11–1.74 | 0.0036b | 0.63 |
| Tumour location (proximal vs distal) | 1.05 | 0.61–1.79 | 0.8606 | ||
| TNM (III vs II) | 2.46 | 1.34–4.50 | 0.0035b | ||
|
OS | |||||
| miR-320e (per 0.0052 unitsa) | 38/167 | 1.46 | 1.11–1.91 | 0.0059b | 0.62 |
| Tumour location (proximal vs distal) | 1.08 | 0.55–2.11 | 0.8251 | ||
| TNM (III vs II) | 2.46 | 1.12–5.37 | 0.0244b | ||
Abbreviations: CI=confidence interval; CRC=colorectal cancer; DFS=disease-free survival; HR=hazard ratio; OS=overall survival; TNM=tumour, node, metastasis.
a
This is the IQR, representing an increase from the 25th percentile to the 75th percentile of the miR-320e distribution.
b
P<0.05.