Table 3. miR-320e expression levels and clinico-pathologic characteristics of stage II and III CRC patients in the validation cohort.
Characteristics stages II–III | Patient number | MiR-320e expression median (range) | P-value |
---|---|---|---|
Age (years) | 67 (32–82)a | ||
Genderb | |||
Male | 96 (57.5%) | 0.00305 (0–0.022) | 0.9638 |
Female | 71 (42.5%) | 0.00300 (0.00033, 0.028) | |
Tumour locationb | |||
Distal | 113 (67.7%) | 0.00310 (0.00023–0.022) | 0.3618 |
Proximal | 54 (32.3%) | 0.00225 (0–0.028) | |
Tumour sizeb | |||
<45 mm | 72 (46.8%) | 0.0025 (0.00013–0.028) | 0.1047 |
>45 mm | 82 (53.2%) | 0.00337 (0–0.019) | |
Tumour gradeb | |||
G1, G2 | 140 (96.6%) | 0.00305 (0.00013–0.028) | 0.1843 |
G3 | 5 (3.4%) | 0.00090(0.00067–0.009) | |
Mucinousb | |||
Yes | 25 (16.3%) | 0.0033 (0–0.018) | 0.9469 |
No | 128 (83.7%) | 0.00285 (0.00013–0.028) | |
Lymph node metastasisb | |||
Yes | 95 (61.7%) | 0.0034 (0.00013–0.022) | 0.0626 |
No | 59 (38.3%) | 0.00200 (0–0.028) | |
TNMb | |||
2 | 65 (38.9%) | 0.002 (0–0.028) | 0.0266c |
3 | 102 (61.1%) | 0.00357 (0.00013–0.022) | |
MMR status | |||
Deficient | 11 | 0.00380 (0.00068–0.018) | 0.5655 |
Proficient | 155 | 0.00300 (0–0.028) |
Abbreviations: CRC=colorectal cancer; MMR=mismatch repair; TNM=tumour, node, metastasis.
Age, is represented as median (range).
Evaluated using Wilcoxon Rank Sum test.
P<0.05.