Table 1. Prostate cancer risk polymorphisms genotyped and analysed in study cohort.
| SNP | Chr | Pos | Major/minor allele | MAFa | Per-allele ORb | Candidate gene | Reference |
|---|---|---|---|---|---|---|---|
| rs1218582 | 1q21 | 153100807 | AG | 0.45 | 1.06 (1.03–1.09) | KCNN3 | Eeles et al, 2013 |
| rs4245739 | 1q32 | 202785465 | AC | 0.25 | 0.91 (0.88–0.95) | MDM4–PIK3C2B | Eeles et al, 2013 |
| rs10187424 | 2p11 | 85647807 | AG | 0.41 | 0.92 (0.89–0.94) | GGCX—VAMP8 | Kote-Jarai et al, 2011 |
| rs1465618 | 2p21 | 43465600 | GA | 0.23 | 1.08 (1.03–1.12) | THADA | Eeles et al, 2013 |
| rs6545977 | 2p15 | 63154668 | GA | NR | NR | OTX1—RPL27P5 | Eeles et al, 2013 |
| rs13385191 | 2p24 | 20751746 | GA | 0.40 | 1.15 (1.10–1.21) | C2orf43 | Takata et al, 2010 |
| rs11902236 | 2p24 | 10035319 | GA | 0.27 | 1.07 (1.03–1.10) | TAF1B:GRHL1 | Eeles et al, 2013 |
| rs3771570 | 2q37 | 242031537 | GA | 0.15 | 1.12 (1.08–1.17) | FARP2 | Eeles et al, 2013 |
| rs7584330 | 2q37 | 238051966 | TC | 0.22 | 1.06 (1.02–1.09) | COL6A3 - MLPH | Kote-Jarai et al, 2011 |
| rs7629490 | 3p11 | 87324187 | CT | NR | 1.06 (1.04–1.09) | VGLL3 - CHMP2B | Schumacher et al, 2011 |
| rs9284813 | 3p12 | 87234859 | AG | NR | NR | VGLL3 - CHMP2B | Takata et al, 2010 |
| rs7611694 | 3q13 | 114758314 | AC | 0.41 | 0.91 (0.88–0.93) | SIDT1 | Eeles et al, 2013 |
| rs6763931 | 3q23 | 142585522 | CT | 0.45 | 1.04 (1.01–1.07) | ZBTB38 | Kote-Jarai et al, 2011 |
| rs4857841 | 3q21 | 129529333 | GA | 0.30 | 1.13 (1.08–1.18) | EEFSEC | Lindstrom et al, 2012 |
| rs1894292 | 4q13 | 74714193 | GA | 0.48 | 0.91 (0.89–0.94) | AFM,RASSF6 | Eeles et al, 2013 |
| rs17021918 | 4q22 | 95781900 | CT | 0.34 | 0.90 (0.87–0.93) | PDLIM5 | Eeles et al, 2013 |
| rs12500426 | 4q22 | 95733632 | CA | 0.46 | 1.08 (1.05–1.12) | PDLIM5 | Eeles et al, 2013 |
| rs7679673 | 4q24 | 106280983 | CA | 0.45 | 0.91 (0.88–0.94) | RPL6P14–TET2 | Eeles et al, 2013 |
| rs2121875 | 5p12 | 44401301 | TG | 0.34 | 1.05 (1.02–1.08) | FGF10 | Kote-Jarai et al, 2011 |
| rs4466137 | 5q14 | 83021495 | TG | NR | NR | HAPLN1 | Murabito et al, 2007 |
| rs2242652 | 5p15 | 1333027 | GA | 0.19 | 0.87 (0.84–0.90) | TERT | Kote-Jarai et al, 2011 |
| rs12653946 | 5p15 | 1948829 | CT | 0.50 | 1.31 (1.20–1.42) | IRX4 - IRX2 | Takata et al, 2010 |
| rs6869841 | 5q35 | 172872032 | GA | 0.21 | 1.07 (1.04–1.11) | FAM44B (BOD1) | Eeles et al, 2013 |
| rs2273669 | 6p21 | 109391882 | AG | 0.15 | 1.07 (1.03–1.11) | ARMC2,SESN1 | Eeles et al, 2013 |
| rs339331 | 6q22 | 117316745 | TC | 0.31 | 1.28 (1.17–1.40) | GPRC6A;RFX6 | Takata et al, 2010 |
| rs1933488 | 6q25 | 153482772 | AG | 0.41 | 0.89 (0.87–0.92) | RSG17 | Eeles et al, 2013 |
| rs651164 | 6q25 | 160551785 | GA | NR | 0.87 (0.83–0.91) | LOC100289162 | Schumacher et al, 2011 |
| rs12155172 | 7p15 | 20767731 | GA | 0.20 | 1.05 (0.98–1.10) | RPS26P30–ASS1P11-SP8 | Eeles et al, 2013 |
| rs2928679 | 8p21 | 23494920 | CT | 0.42 | 1.05 (1.01–1.09) | SLC25A37 NKX3-1 | Eeles et al, 2013 |
| rs1512268 | 8p21 | 23582408 | GA | 0.45 | 1.18 (1.14–1.22) | SLC25A37 - NKX3-1 | Eeles et al, 2013 |
| rs11135910 | 8p21 | 25948059 | GA | 0.16 | 1.11 (1.07–1.16) | EBF2 | Eeles et al, 2013 |
| rs10086908 | 8q24 | 128011937 | TC | 0.3 | 0.87 (0.81–0.94) | POU5F1B, MYC | Eeles et al, 2013 |
| rs12543663 | 8q24 | 127993841 | AC | 0.33 | 1.08 (1.00–1.16) | LOC727677, MYC | Al Olama AA et al, 2009 |
| rs13252298 | 8q24 | 128164338 | AG | NR | 0.89 (0.85–0.95) | FAM84B - SRRM1P1 | Schumacher et al, 2011 |
| rs445114 | 8q24 | 128392363 | TC | 0.36 | 1.14 (1.10–1.19) | SRRM1P1 - POU5F1B | Gudmundsson et al, 2010 |
| rs16902094 | 8q24 | 128320346 | AG | 0.15 | 1.21 (1.15–1.26) | SRRM1P1 - POU5F1B | Gudmundsson et al, 2010 |
| rs817826 | 9q31 | 107235855 | TC | 0.10 | 1.43 (1.17–1.77) | RAD23B-KLF4 | Xu et al, 2010 |
| rs2252004 | 10q26 | 122844709 | GT | 0.23 | 1.16 (1.10–1.22) | NR | Akamatsu et al, 2012 |
| rs11199874 | 10q26 | 123022509 | GA | 0.29 | 2.9 (2.1–4.1) | RPL19P16-FGFR2 | Nam et al, 2006 |
| rs1938781 | 11q12 | 58915110 | TC | 0.3 | 1.16 (1.11–1.21) | FAM111A | Akamatsu et al, 2012 |
| rs11228565 | 11q13 | 68735156 | GA | 0.2 | 1.23 (1.16–1.31) | TPCN2 - MYEOV | Gudmundsson et al, 2010 |
| rs7127900 | 11p15 | 2233574 | GA | 0.20 | 1.22 (1.17–1.27) | IGF2-INS | Eeles et al, 2013 |
| rs11568818 | 11q22 | 101906871 | AG | 0.44 | 0.91 (0.88–0.94) | MMP7 | Eeles et al, 2013 |
| rs10875943 | 12q13 | 47962277 | TC | 0.31 | 1.07 (1.04–1.10) | TUBA1C-PRPH | Kote-Jarai et al, 2011 |
| rs1270884 | 12q24 | 113169954 | GA | 0.49 | 1.07 (1.04–1.10) | TBX5 | Eeles et al, 2013 |
| rs1529276 | 13q33 | 102726008 | TA | NR | NR | SLC10A2-RPL7P45 | Murabito et al, 2007 |
| rs8008270 | 14q22 | 52442080 | GA | 0.18 | 0.89 (0.86–0.93) | FERMT2 | Eeles et al, 2013 |
| rs7141529 | 14q24 | 68196497 | AG | 0.50 | 1.09 (1.06–1.12) | RAD51B | Eeles et al, 2013 |
| rs11650494 | 17q12 | 44700185 | GA | 0.08 | 1.15 (1.09–1.22) | GNGT2, ABI3, PHB, SPOP, HOXB13 | Eeles et al, 2013 |
| rs7241993 | 18q23 | 74874961 | GA | 0.30 | 0.92 (0.89–0.95) | SALL3 | Eeles et al, 2013 |
| rs8102476 | 19q13 | 38735613 | CT | 0.46 | 1.12 (1.08–1.15) | DPF1 - PPP1R14A | Gudmundsson et al, 2010 |
| rs103294 | 19q13 | 54797848 | TC | 0.30 | 1.28 (1.21–1.45) | LILRA3 | Xu et al, 2010 |
| rs2427345 | 20q13 | 60449006 | GA | 0.37 | 0.94 (0.91–0.97) | GATAS, CABLES2 | Eeles et al, 2013 |
| rs6062509 | 20q13 | 61833007 | AC | 0.30 | 0.89 (0.66–0.92) | ZGPAT | Eeles et al, 2013 |
| rs742134 | 22q13 | 41842773 | AG | NR | 1.16 (1.01–1.23) | BIK | Schumacher et al, 2011 |
| rs5759167 | 22q13 | 41830156 | GT | 0.47 | 0.86 (0.83–0.88) | RPS25P10-BIK | Eeles et al, 2013 |
Abbreviations: candidate gene=nearby gene as reported in the cited literature; Chr=chromosome; MAF=minor allele frequency; NR=not reported; OR=previous odds ratio for the SNP as cited by the given paper; Pos=chromosomal location; SNP=single-nucleotide polymorphism.
a
Data for MAFa are taken from the original publication (Ref).
b
Data for Per-Allele OR are taken from the original publication (Ref). 95% confidence intervals are given in brackets where available.