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. 2015 Jun 2;113(1):159–165. doi: 10.1038/bjc.2015.185

Table 2. Associations between alcohol consumption and volumetric mammographic density among all women.

      β (95% Confidence interval)
 
Absolute dense volume (cm3)
Per cent dense volume (%)
Alcohol consumption (g per day) N % Unadjusted Multivariable adjusteda Unadjusted Multivariable adjusteda
0 9728 18.3 Ref. Ref. Ref. Ref.
0.1–4.9 13 437 25.3 −0.6 (−1.5, 0.3) −0.2 (−0.8, 1.1) 1.0 (0.9, 1.2) 0.3 (0.2, 0.4)
5.0–9.9 19 659 37.1 −1.6 (−2.4, −0.8) 0.5 (−0.4, 1.4) 1.2 (1.0, 1.3) 0.3 (0.2, 0.4)
10.0–19.9 3538 6.7 −0.8 (−2.1, 0.5) 0.9 (−0.5, 2.2) 1.0 (0.8, 1.2) 0.4 (0.3, 0.6)
20.0–29.9 5635 10.6 −1.7 (−2.8, −0.6) 1.3 (0.2, 2.5) 0.5 (0.3, 0.6) 0.2 (0, 0.3)
30.0–40.0 1063 2.0 1.6 (−0.5, 3.7) 4.5 (2.2, 6.8) 0.3 (0, 0.6) 0.5 (0.2, 0.8)
Pglobalb     <0.001 <0.001 <0.001 <0.001
For every 10 g per day increasec     −0.2 (−0.5, 0.2) 0.9 (0.5, 1.3) 0 (0, 0.1) 0.1 (0.02, 0.1)
Ptrendd     0.34 <0.001 0.86 0.01

Abbreviations: β=regression coefficient; CI=confidence interval.

a

Regression coefficients were adjusted for age at mammography (5-year categories), body mass index (<25.0, 25.0–29.9, and ⩾30.0 kg m−2), family history of breast cancer in mother or sisters (yes, no), age at menarche (<13, 13, 14, and ⩾15 years), parity and age at first birth (nulliparous; 1–2 births, age at first birth<26 years; 1–2 births, age at first birth ⩾26 years, ⩾3 birth; age at first birth <26 years; ⩾3 births, age at first birth ⩾26 years), oral contraceptives use (never, ever), menopausal status (pre/postmenopausal), hormone replacement therapy use (never, past, current), education level (secondary school, high school, university or higher, other), smoking status (never, past, current), physical activity (<40.0, 40.0–44.9, 45.0–49.9, and ⩾50.0 metabolic equivalent hours per day), and ethnicity (having a European ancestry; yes or no).

b

Pglobal values were obtained from regression models using alcohol consumption as a categorical exposure.

c

Change in absolute dense volume for every 10 g per day increase in alcohol consumption, from regression models with alcohol consumption as a continuous exposure.

d

Ptrend values were obtained from regression models using alcohol consumption as a continuous exposure.